Dr. Kadharbatcha S. Saleem - Mapping the Primate Connetome in 3D
Title: Mapping the Primate Connetome in 3D
Speaker: Dr. Kadharbatcha S. Saleem, NIH, USA
Chair: Dr. Shan Yu, Brainnetome Center, CASIA
Time: 09:30-10:30 July 20, 2016
Venue: The 1st meeting room, 3rd floor of the Intelligence Building
Until recently, researchers have relied largely on printed articles and atlases for connectivity information and anatomical references. While useful, this traditional format can be difficult to combine with imaging studies where the interconnections of numerous areas need to be considered simultaneously. Here I present a new software interface (AFNI/SUMA) to show the detailed connectome of different cortical and subcortical areas in the macaque monkey in both 2D and 3D interactive formats using data derived from anatomical tracing methods. This connectivity atlas can readily be merged with the users' own MRI data.
I will also discuss on the followings topics with reference to this connectome, and our recent work:
• How reliable is Diffusion MRI tractography in constructing large-scale connectome?
• Why it is crucial to complement tractography results with a combination of histological (tracing) methods to map structural connectivity accurately?
• Why it is important to combine different methods (fMRI, electrophysiology, and anatomical tracing) in the same animal to map the structural and functional networks accurately?
• Finally, Why it is important to support inferences about the organization of pathways in the human with data from animal models ("Macaque connectome")?.
Dr. Kadharbatcha Saleem has been working on the structural and functional organization of higher brain areas for the past 20 years. He has maintained several collaborations with institutions across different continents (Japan, Germany, and USA) on various projects since 1995. Dr. Saleem attained a B.S and M.S in zoology from Madras University, India. He subsequently received his Ph.D in Neuroanatomy from the same University. Following his thesis work, Saleem carried out his research work related to higher brain functions in Riken Brain Science Institute, Japan, Washington University in Saint Louis, and Max‐Planck Institute in Germany. He is currently working in the Lab of Neuropsychology, National Institute of Mental Health (NIMH/NIH) in Bethesda, USA. His main interest is the study of functionally less explored regions in the brain, particularly the prefrontal and temporal cortex. A few years ago Saleem in collaboration with Dr. Nikos Logothetis at the Max‐Planck Institute in Germany published a book, "A Combined MRI and Histology Atlas of the Rhesus Monkey Brain in Stereotaxic Coordinates" (2007 and 2012; Elsevier/Academic Press). This atlas has come to be recognized as the finest atlas of the Rhesus monkey brain because of its exquisite attention to detail and combination with MRI. This atlas is designed to provide an easy to use resource/reference for anatomical, physiological, and functional imaging (fMRI, PET, and MEG) studies in primates. Recently he has completed the 3D digital template atlas of the macaque brain with many updates. Dr. Saleem has been conducting Human Neuroscience course for Postbac, Postdoc, Ph.D., Premed, and MD students in NIMH (Lab Neuropsychol.), NIH (FAES), and Washington University school of Medicine in St. Louis.